• Introduction Rotavirus RV a member of Reoviridae family

  2019-11-27

  

  Introduction Rotavirus (RV), a member of Reoviridae family, is a non-enveloped virus which has a double-stranded RNA genome of 11 segments surrounded by three concentric protein layers. It has been reported to cause estimated 25% of moderate-to-severe illnesses (Kotloff et al., 2013) and 30% of tot

• The focus of this review is on the diacylglycerol acyltransf

  2019-11-27

  

  The focus of this review is on the diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) enzymes, DGAT1 and DGAT2, that catalyze the esterification of a fatty acyl moiety to a DAG molecule to produce TAG. These enzymes commit DAG to being stored as TAG rather than being diverted for the synthesis of ph

• br DDR role in kidney Thirty eight papers are reported

  2019-11-27

  

  DDR1 role in kidney Thirty-eight papers are reported in PubMed upon the keyword search “DDR1 AND kidney”. Careful examination of those papers shows that only 31 are related to DDR1\'s role in glomerulosclerosis and renal fibrosis, 24 of those being research and the rest review articles. Since th

• The aberrant methylation of genes

  2019-11-27

  

  The aberrant methylation of genes that suppress tumorigenesis appears to occur early in tumor development and increase progressively, eventually leading to the malignant phenotype [35]. Genes involved in every step of tumorigenesis can be silenced by this epigenetic mechanism. Hypermethylation of pr

• It has previously been shown

  2019-11-27

  

  It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of kainic acid on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that th

• br Introduction Cell transplantation therapies using embryon

  2019-11-27

  

  Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or SCH527123 have emerged as therapeutic options for retinal degeneration following recent breakthroughs. A number of groups have shown tha

• br Introduction Epithelial mesenchymal transition EMT is a

  2019-11-27

  

  Introduction Epithelial-mesenchymal transition (EMT) is a biological process by which epithelial MLCK inhibitor peptide 18 lose cell polarity and cell-cell adhesion, and gain mesenchymal features with an increase of migratory and invasive properties [1]. EMT is essential for mesoderm formation d

• br Conflict of Interest br

  2019-11-27

  

  Conflict of Interest Acknowledgements Marques F. was supported by the Foundation for Science and Technology (FCT), Portugal, Grant UMINHO/BI/35/2012. This work was supported by FCT by the Project PTDC/AGR-AAM/70418/2006. Introduction β-methylamino-l-alanine (BMAA) exposure has long been as

• br Conclusion br Competing interests br Authors contribution

  2019-11-27

  

  Conclusion Competing interests Authors\' contributions Acknowledgements The work was supported by Aurigene Discovery Technologies (M) Sdn. Bhd., Industrial Doctoral Program sponsorship by Ministry of Higher Education, Malaysia and research grants by the University of Malaya, grant number

• Psalmotoxin 1 australia Dexamethasone DEX a potent synthetic

  2019-11-27

  

  Dexamethasone (DEX), a potent synthetic glucocorticoid drug, is effective for treatment of a range of inflammatory and autoimmune conditions as well as the reduction of side effects associated with chemotherapy. On the Czech Republic pharmaceutical market, DEX is incorporated into eighteen drugs use

• br Conflicts of interest br Introduction Arylamine N acetylt

  2019-11-26

  

  Conflicts of interest Introduction Arylamine N-acetyltransferase 1 (NAT1, EC 2.3.1.5) is a cytosolic enzyme that catalyses the acetylation of small molecule arylamines, hydrazines and sulphonamides (Hein, 2002). Found in most N1-Methylpseudo-UTP in the body, NAT1 expression is regulated at th

• Multivariate models take interactions between cytokines into

  2019-11-26

  

  Multivariate models take interactions between cytokines into account and were used to accurately distinguish samples from different time points in pregnancy. The distinction accuracy did not increase with increasing time between the gestational time points, indicating that the cytokine development d

• AQP protein expression was determined by Western

  2019-11-26

  

  AQP4 protein expression was determined by Western blot analysis. Briefly, protein samples (50μg) from brains or astrocytes were separated by 12% SDS–polyacrylamide gel electrophoresis and transferred to nitrocellulose membranes. The membranes were reacted with a rabbit polyclonal antibody against AQ

• GSK1210151A receptor Here we found that these leukotriene an

  2019-11-26

  

  Here we found that these leukotriene antagonists also inhibit the effects of nucleotides acting at P2Y receptors in dU937 cells, which are known to express a number of nucleotide receptors, such as P2Y2 or P2Y4[30]. In an effort to characterize the P2 receptor subtypes subject to negative modulation

• We next considered the mechanism of the hepatospecific decre

  2019-11-26

  

  We next considered the mechanism of the hepatospecific decrease in CYP3A exerted by EGCG. We examined the possibility that orally administered EGCG was absorbed from the intestine and directly decreased the CYP3A expression level in the liver. Although the neurokinin 1 receptor rate of orally admin

16254 records 931/1084 page Previous Next First page 上5页 931932933934935 下5页 Last page