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Placental insufficiency is regarded as the
2019-07-02
Placental insufficiency is regarded as the main etiology for FGR. Placental development is highly unique in eutherians and is regulated by numerous factors. For example, the novel retrotransposon-derived gene retrotransposon-like 1 (RTL1) was recently shown to play a key role in placental developmen
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It should be noted that there
2019-07-02
It should be noted that there are other methods, such as artificial intelligence, like Artificial Neural Networks/ANN (such as PSO-ANN, ICA-ANN), Least Square Support Vector Machine/LSSVM, etc. [10], [11], [12], [13], [14], [15], [16], [17], [18], or molecular simulations, for modeling the fluid\'s
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There is a considerable molecular genetic heterogeneity
2019-07-02
There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions. Furthermore, for either gene fusion, additional heterogeneity stems from the location of the genomic breakpoints of the translocation, resulting in diffe
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The ADME profile of AAT was
2019-07-02
The ADME profile of AAT-008 () was very promising, with high stability in HLM. The pre-clinical pharmacokinetic properties of AAT-008 were also assessed in rats (Sprague-Dawley, male), dogs (beagle, male), and monkeys (cynomolgus, male). The experimentally determined parameters are summarized in . A
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The structure of the HOIP RBR LDD module bound to
2019-07-02
The structure of the HOIP RBR–LDD module bound to UbcH5~Ub reveals insights into an activated HOIP component [47]. Contacts between the E2~Ub and the non-cognate RBR module in the crystal suggest how a structure in which the active sites of the E2 and the E3 are in close proximity might look. In thi
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P H is a nonheme iron II
2019-07-01
P4H is a nonheme iron(II) dioxygenase that uses O2 and α-ketoglutarate as co-substrates (Fig. 1A). The three-dimensional structure of mammalian P4H is unknown. We reasoned that an electrophilic analog of α-ketoglutarate could serve as an irreversible inhibitor of the enzyme and, hence, a useful prob
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Chk is dramatically induce by the IL
2019-07-01
Chk is dramatically induce by the IL-4 family of cytokines and equally dramatically inhibited by IFN-γ, a regulation that appears to be specific for human monocytes. In primary human T cells, Chk is not normally present, but it can be induced by potent activators of T PF-9184 structure such as PHA
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A recent report has shown that C elegans homozygous for
2019-07-01
A recent report has shown that C. elegans homozygous for a point mutation within the HORMA domain of HTP-1 (M127K), which disrupts its association with chromosome axes, displayed an extended zone of PLK-2 localization to PCs in response to asynapsis (Silva et al., 2014), which, as we show here, is a
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Berner et al used a
2019-07-01
Berner et al used a meta-analysis to show that sildenafil resulted in an effect of 9.65-point improvement. Tadalafil could be pooled into an effect of 8.52-point improvement, and vardenafil showed an effect of 7.50-point improvement. In our present studies, 200 mg udenafil resulted in an effect of 8
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br Preoperative rehabilitation Severe pulmonary function
2019-07-01
Preoperative rehabilitation Severe pulmonary function impairment was considered inoperable in approximately 37% of patients with anatomically resectable lung cancer. The surgical morbidity and mortality rates for patients at an acceptable risk of perioperative complications were 31.6% and 4.3%, r
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The final variant deals with a patient
2019-07-01
The final variant deals with a patient who has a poor prognosis due to visceral metastases and who suffers from a single site of painful bone disease. The purpose of the case was to evaluate the panel\'s views of supportive care with analgesic medications plus or minus EBRT. The group did recommend
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In patients who develop bone metastases these are commonly d
2019-07-01
In patients who develop bone metastases, these are commonly diagnosed at the time of their initial work up for their metastatic disease (∼80%) [7], although others can develop skeletal metastases at any time during the disease course. The consequences of bone metastases include pain (∼80%) [3,6,8] a
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Human ether a go go
2019-07-01
Human-ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly-activating delayed-rectifier potassium leukotriene b4 molecular that generate IKr. This outward potassium current is elicited during the plateau phase of action potentials and is required for repolarization [4]. After being tr
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El juego de las apariencias y la obtenci n
2019-07-01
El juego de las apariencias y la obtención de un estatus no son privativos de los consumidores del arte en este texto: coleccionistas, guías de museo o críticos improvisados. El cuento “Borges y el ultraísmo”, también del libro Amores de segunda mano (1991), ubicará la discusión directamente en los
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Immediate rollout of an effective and safe short course
2019-07-01
Immediate rollout of an effective and safe short-course treatment regimen is essential for the attack phase of the visceral leishmaniasis elimination programme, which aims to reduce the incidence to less than one case per 10 000 Immunology Inflammation Compound Library of at risk. A single-dose lip
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