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br Regulation of cadherin switching The downregulation of
2020-03-13
Regulation of cadherin switching The downregulation of E-cadherin during cadherin switching is induced by multiple mechanisms, including methylation of the E-cadherin promoter and signaling pathways that activate E-cadherin-suppressing transcription factors [[61], [62], [63]]. During the progress
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Indeed some cancers may even be defined by dysregulated cycl
2020-03-13
Indeed, some cancers may even be defined by dysregulated cyclin and thus CDK activity: mantle cell lymphoma, an uncommon lymphoma of mature B cells, is defined by the presence of overexpressed cyclin D1, usually as a result of a translocation between chromosomes 11 and 14 with the net result that cy
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The significance of the two biomarkers for the detection
2020-03-13
The significance of the two biomarkers for the detection of Aspergillus antigen and DNA in the sputum of patients cannot be over-emphasised. The mean GMI value was higher among CPA patients than the ABPA. This might not be unconnected with the fact that CPA is associated with lung damage and pre-exi
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br Experimental br Results and discussion br Conclusion br
2020-03-13
Experimental Results and discussion Conclusion Acknowledgements This work was funded by the National Natural Science Foundation of China (81572080, 81873972and81873980), the National Science and Technology Major Project of the Ministry of Science and Technology of China (2018ZX10732202),
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Recoverin is a kDa retinal protein that binds to calcium
2020-03-13
Recoverin is a 23-kDa retinal protein that binds to calcium. It regulates the nonreceptor tyrosine kinase of rhodopsin during visual transduction within photoreceptor cells. Since the pathogenicity of anti-recoverin antibody is potent, anti-recoverin CAR patients often have progressive visual impai
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br Transparency document br Acknowledgments This study was f
2020-03-13
Transparency document Acknowledgments This study was funded by ICMR, Govt. of India. Alisha Dhiman acknowledges UGC-DSKPDF, India for post-doctoral fellowship and Monisha Gopalani acknowledges CSIR, India for Senior Research Fellowship. AIRF, JNU is acknowledged for TEM, confocal microscopy an
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Introduction CYP is a superfamily of heme containing monooxy
2020-03-13
Introduction CYP450 is a superfamily of heme-containing monooxygenases, many of which are expressed in the liver, and they are significant phase-I lcq mg in drug metabolism and detoxification. There are three subfamilies (CYP1, CYP2 and CYP3) that are mainly involved in the metabolism of drugs in b
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Multi subunit RING type E ligases are exemplified
2020-03-13
Multi-subunit RING-type E3 ligases are exemplified by the CULLIN-RING-ligase (CRL) and the anaphase-promoting complex/cyclosome (APC/C) [19]. CRLs constitute the biggest family of other multi-component E3 ligases. These consist of a cullin scaffold protein (CULLIN 1, 2, 3, 4A, 4B, 5, 7), a substrate
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Introduction Amphetamine AMPH methamphetamine MA and ethylen
2020-03-13
Introduction Amphetamine (AMPH), methamphetamine (MA), and 3,4-ethylenedioxymethamphetamine (MDMA) are widely abused psychoactive substances, with the basic chemical structure of phenylethylamine [1]. The abuse of these drugs is associated with psychostimulant, anorectic and hallucinogenic properti
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For reductive amination by L
2020-03-12
For reductive amination by L-AmDH, the term related to the enzyme-ammonia complex is excluded rather than the enzyme-pentanone term (Table 1). If this were an ordered mechanism, this would imply ammonia binds second, after NADH and before 2-pentanone. However, a large KM,NH4 value renders ammonia bi
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The regression also revealed a
2020-03-12
The regression also revealed a significant association between admission selectivity (SELECT) and exam pass rate (PASS%) (p CGS 21680 HCl serve as an indicator of a student’s ability to learn and their aptitude for academic success. These same qualities likely enable more selective schools to design
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Patients and methods This study was
2020-03-12
Patients and methods This study was performed at 3 academic centers (Chung-Ang University YongSan Hospital, Soonchunhyang University Hospital, and Chung-Ang University Hospital) in Seoul, Korea, from November 2008 to November 2010. The study protocol was approved by the institutional review boards
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ER redox imbalance leads to the accumulation
2020-03-12
ER redox imbalance leads to the accumulation of misfolded proteins, which might trigger the unfolded protein response (UPR) [17]. In the initiation of UPR, GRP78 preferentially binds to unfolded proteins, shifting the binding equilibrium away from IRE-1, PERK, and ATF-6, the initiators of UPR [18].
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br Coactivator Binding Sets APC C Catalytic Core
2020-03-12
Coactivator Binding Sets APC/C Catalytic Core in Motion A coactivator not only recruits substrates to APC/C [18] (Figure 3B), but also stimulates repositioning of the catalytic core 19, 24. High-resolution cryo-EM maps of apo forms of APC/C without a coactivator show the catalytic core and platfo
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The potential off target activity of
2020-03-12
The potential off-target activity of against other ATP-dependent enzymes, such as kinases, was also investigated. Encouragingly, there was no significant inhibition of ATP binding to 97 human kinases, when was evaluated at 10μM within a DiscoveRx scanEDGE® kinome screen (, ). All together, these d
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