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The fact that the in vitro induction of osteogenic
2018-11-08
The fact that the in vitro induction of osteogenic differentiation leads to sarcoma development from sarcoma iPSCs in concert with EWS-FLI1 expression indicates that these sarcomas arise from osteogenic progenitor cells. However, it is important to note that the withdrawal of EWS-FLI1 in osteosarcom
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These data suggest that niches are not limited
2018-11-07
These data suggest that niches are not limited to the governance of stem cells (Wu et al., 2009; Yu et al., 2015a), and the definition of “progenitor niches” may offer new ways to understand the regulation of tissue composition and function. We recently demonstrated that selective deletion of cells
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AVE 0991 In this context companies face the process of build
2018-11-07
In this context, companies face the process of building and maintaining relationships that prove to be valuable for both customers and the company. Considering a proposal of integrating the TOE model (Technology–Organization–Environment) and the focus on relationship management applied to the m-mark
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This flow budget constraint can be written
2018-11-07
This flow budget constraint can be written as a government stock budget constraint by using standard procedure. First, multiply both sides of the flow constraint by exp(−rx), where r is the real rate of interest. Then, by taking into account thatwe can writewhere s(m)=rm+τ(m) is a measure of the val
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We analyze papers that Lucas published
2018-11-07
We analyze 27 papers that Lucas published between 1967 and 1981, as reported in his own public curriculum vitae. Replies, the erratum of Some international evidence and review articles are absent from that list. The same is true of his 1977 paper, A Report to the OECD by a group of independent exper
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br Authorship contributions br Disclosure
2018-11-07
Authorship contributions Disclosure of conflicts of interest Acknowledgements Introduction Melanomas are among the most commonly occurring cancers. Crude incidence rates in Australia (AIHW, 2014) and the USA (SEER, 2014) were approximately 50 cases (in 2010) and 20 cases (in 2011) per 10
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Neurotrophic factors regulate RGC survival and neurite
2018-11-07
Neurotrophic factors regulate RGC survival and neurite growth through both common and distinct downstream signaling pathways (Goldberg et al., 2002). For example, MAPK/ERK and PI3K/AKT signaling pathways are involved in BDNF induced neuronal survival and axonal growth (Nakazawa et al., 2002) whereas
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To evaluate the capacity of
2018-11-07
To evaluate the capacity of the newly isolated recombinants to express BHV-1 UL49.5, total protein was isolated from virus-infected cells and analyzed by immunoblotting. BHV UL49.5 protein only accumulated in BV49.5-infected cells and was not detected in cells infected with the BV49.5-FS variant, wi
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McCaw et al s work adds important information to
2018-11-07
McCaw et al.\'s work () adds important information to the growing knowledge regarding the effect of lipids on CLL cell biology, however numerous unknowns remain. For example, molecular prognostic markers in the CLL patients in these experiments are not fully detailed, LPL levels are unknown, and ser
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Protein tyrosine phosphatase B PTP B is a
2018-11-07
Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor tyrosine phosphatase that is widely expressed in the body, and negatively regulates leptin signaling by dephosphorylating Janus Activating Kinase 2 (JAK2) in the hypothalamus (Tsou and Bence, 2012; Myers et al., 2001; Zhang et al., 2015). Ani
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As opposed to schwannomas other
2018-11-07
As opposed to schwannomas, other driver mutations have been identified in meningioma, but those are mutually exclusive of Merlin (Clark et al., 2013). In order to keep the genetic background consistent with schwannoma, we analysed only Merlin-deficient WHO grade I meningiomas. Comparative functional
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Despite viral etiologies driving most cases of acute respira
2018-11-07
Despite viral etiologies driving most cases of acute respiratory infection, definitive diagnostic tools for these syndromes are lacking. Even highly sensitive pathogen-specific tests such as PCR are dependent upon proper sampling technique and inclusion of virus-type-specific reagents and processing
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The rationale for use of FASN inhibitors
2018-11-07
The rationale for use of FASN inhibitors as a key component of combination therapy derives from known cellular effects of FASN inhibition (Ventura et al., 2015; Chuang et al., 2011; Kridel, 2004; Puig et al., 2009, 2008; Tomek et al., 2011) that include (1) blockade of palmitate synthesis, (2) disru
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Basically circadian rhythms are recurrent patterns
2018-11-07
Basically, circadian rhythms are recurrent patterns in numerous physiological processes that have been documented even in plants and cyanobacteria, in addition to animals, within a period of one day. The ATP/ADP ratios in cyanobacterial citco Supplier and sunflower roots are actually higher in the
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Although low baseline virus load is considered one of
2018-11-07
Although low baseline virus load is considered one of the predictive factors for SVR12, many other host, virus and drug related factors are also important and can sometimes affect the virus response to treatment regardless of baseline virus load. The significant existence of Resistance Associated Su
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