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Finally we observed decreased leukocyte influx in exosome tr
2018-11-12
Finally, we observed decreased leukocyte influx in exosome treated animals. It is likely that the reduced influx is secondary to the reduced cardiac injury after exosome treatment, since leukocyte influx did not differ between the groups at 1h reperfusion. In addition, we found that the reduced infa
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One of the major transduction pathways
2018-11-12
One of the major transduction pathways for apelin signal depends on the interaction with a Gi-protein coupled to the APJ receptor, independently of Ras protein; although dependent on Protein Kinase C (PKC) (Masri et al., 2005). In addition to the adenyl cyclase inhibition pathway, apelin activates E
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Introduction The vascular endothelium the single cell layer
2018-11-12
Introduction The vascular endothelium, the single-cell layer lining blood vessels, is a multifunctional interface that displays a striking phenotypic plasticity necessary for maintaining vascular homeostasis. In this context, the vascular endothelium is critical to initiate an inflammatory response
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Our previous study Ara et al demonstrated the protective
2018-11-12
Our previous study (Ara et al., 2011) demonstrated the protective efficacy of hypoxic-preconditioning against hypoxic–ischemic injury in newborn piglet model. We showed that hypoxic exposure for 3h, 24h before hypoxia–ischemia, was effective in reducing Avasimibe damage in newborn piglets while its
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In order to enhance osteochondral commitment
2018-11-12
In order to enhance osteochondral commitment, we performed chondrogenic pre-induction of ATSC/β-TCP constructs. Ectopic bone formation was installed in more than 75% of samples, suggesting that a sufficient degree of determination was reached to obtain about as much new bone as with non-induced BMSC
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Dental pulp tissue is a highly innervated and
2018-11-12
Dental pulp tissue is a highly innervated and vascularized soft connective tissue which, while encased in dentin, appears to be very vulnerable to external insults such as trauma, chemical irritation or microbial infection (Huang, 2009). Despite the relatively high success rate of traditional endodo
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br Materials and methods br Results br Discussion Recent neu
2018-11-12
Materials and methods Results Discussion Recent neurogenesis studies and the discovery of multipotent neural stem KY02111 derived from the adult mammalian CNS, including that of humans, have had a considerable influence on potential treatments for neural injury (Gross, 2000; Ming and Song,
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br Materials and methods br Results
2018-11-12
Materials and methods Results Teeth were collected from 10 female and 6 male subjects. The subject ages ranged from 6 to 13years old, with an average age of 9. All subjects were typically developing children with no suspicion of undiagnosed neurogenetic disorders. The teeth included in the stu
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The negative regulation of Zac
2018-11-12
The negative regulation of Zac1 expression by SOXB1 transcription factors combined with the decrease of Sox2 expression as the levels of Zac1 increase suggest that ZAC1 and SOXB1 factors could act as a cross-repressive genetic switch governing the acquisition of distinct cellular identities (Enver e
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br Results br Discussion We established
2018-11-09
Results Discussion We established a method of 3D differentiation without feeder phospholipase inhibitor to generate hPSC-derived PAEC spheroids via isolated progenitor cells using CPM as a surface antigen, which is reportedly a biomarker of lung diseases, such as acute pneumonia and lung canc
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The BM lin CD CD
2018-11-09
The BM lin−CD201+CD27+ population significantly overlaps with LSK isosafrole in B6 mice and consists of early HSPCs. Lin−CD201+CD27+ cells have been proposed for alternative HSPC identification in mouse strains (e.g., BALB/c or NOD strains) or under stress conditions, which lack a distinct LSK immu
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The reconstruction of mesons was done using
2018-11-09
The reconstruction of φ-mesons was done using their decay channel into two charged kaons, φ→К+К−. Charged particle tracks were reconstructed in two main tracking detectors of the ALICE experiment: TPC (Time Projection Chamber) and ITS (Inner Tracking System). Because of the high multiplicity of part
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br Literature review br Research
2018-11-09
Literature review Research design Analysis and results The data analysis will consist of exploring the statistical properties of all the items of the scales and testing the validity and reliability of the constructs (Gallarza & Gil, 2006). We will verify the reliability through the inter-it
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Another limitation of this study can be seen in the
2018-11-09
Another limitation of this study can be seen in the relative small number of participants; this was due to significant logistical challenges in recruiting and retaining the participants, especially these from low socio-economic backgrounds. Under the circumstances, and given that the three groups sh
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Two other studies assessed the transcriptomic profile during
2018-11-09
Two other studies assessed the transcriptomic profile during the early hours of sepsis in whole blood (Lissauer et al., 2009; Johnson et al., 2007). Results of both studies revealed increased Ridaforolimus of TLR5 as well as mediators of apoptosis similar to the present study. Overall, the increasi
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