Avasimibe Here we addressed these problems by focusing on co

2018-10-20

Here we addressed these problems by focusing on control of the regional identity of PSC-derived neural progenitors and neurons. The developing neural tube is subdivided into distinct regions along the anteroposterior (A-P) and dorsoventral (D-V) axes, and each region produces a specific subtype of n

Nishi et al a b have developed a method of

2018-10-20

Nishi et al. (2014a, 2014b) have developed a method of inducing cancer stem-like na+/ca2+ exchanger (CSCs) through the reprogramming and partial differentiation of the immortalized but otherwise normal MCF10A human mammary epithelial cell line. To experimentally test our computational model of onco

It has previously been reported that differentiation of hESC

2018-10-20

It has previously been reported that differentiation of hESCs without the embryonic body stage led to an increase in the capacity of hESCs to differentiate into osteogenic progenitor mct2 inhibitor (Karp et al., 2006). Consistent with these findings, our differentiation culture method resulted in ce

Since hiPSC CMs can mature in vitro over time

2018-10-20

Since hiPSC-CMs can mature in vitro over time in culture (Lundy et al., 2013), they may prove valuable for investigating the developmental time course of early-stage cardiac diseases, representing a unique platform to predict adverse prenatal outcomes and to develop therapies. We reported FCM hiPSC-

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments B.Z. was supported by an NYSTEM post-doctoral training fellowship, The SKI Stem Cell Research Facility is supported by NYSTEM grants C029153 and C024175 and The Starr Foundation. The work was further supported in part by NIH/NCI g

The importance of the interaction between fibroblasts and CM

2018-10-20

The importance of the interaction between fibroblasts and CMs in cardiac hypertrophy has been previously demonstrated. In neonatal rat and mouse CMs, hypertrophy was dependent on exposure to fibroblasts or their conditioned media, and was mediated by Vadimezan paracrine TGFβ1 release (Fredj et al.,

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2018-07-29