• Another research group assessed pairs of middle aged years

  2023-09-23

  

  Another research group assessed 8503 pairs of middle-aged ( allocated into four groups: 1) major surgeries; 2) knee and hip arthroplasty; 3) minor surgeries; 4) others. Results from five cognitive studies were compared between twins. Confounding of genetic and environmental factors were assessed in

• The finding that OCT is

  2023-09-23

  

  The finding that OCT3 is expressed in the nucleus accumbens (Gasser et al., 2009) suggests that inhibition of this transporter may underlie previously described effects of glucocorticoids on extracellular DA concentrations and indicates that DA clearance in this region is not mediated exclusively by

• To investigate further the clinical and mutational spectrum

  2023-09-22

  

  To investigate further the clinical and mutational spectrum associated with -related dyskinesia, we here performed a screen in a large series of patients affected with an unexplained hyperkinetic movement disorder, resulting in the identification of 2 pediatric patients presenting with a novel pheno

• Another open question is whether GABA

  2023-09-22

  

  Another open question is whether GABA and ACh are released from the same synaptic vesicles, or even the same presynaptic terminals. Multi-transmitter neurons may either function through co-release, in which multiple neurotransmitters are packaged into the same presynaptic terminal and are therefore

• Firms are subject to corporate taxation and face either

  2023-09-22

  

  Firms are subject to corporate taxation, and face either an ACE or a CBIT tax scheme. The two tax regimes achieve financing neutrality by treating debt and equity equally, but differ according to whether deduction of capital costs from the corporate tax Dimesna is allowed or not. While ACE allows fo

• br Results and discussion br Conclusions

  2023-09-22

  

  Results and discussion Conclusions In this report we present the synthesis, structure determination, and the in vitro and in vivo evaluation of a series of new quinone analogues aiming to find novel lead structures for the development of 5-LO inhibitors. Our findings support that also the hydr

• br Conclusion br Conflicts of interest br Introduction RNA i

  2023-09-22

  

  Conclusion Conflicts of interest Introduction RNA interference is a specific post-transcriptional gene silencing mechanism within a cell via the transfection of microRNAs (miRNA), exogenous small interfering RNAs (siRNA) or small hairpin RNAs (shRNA) [1–3]. Transfection of shRNA can be done

• If the lack of specificity and the high pleiotropy

  2023-09-22

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it LY364947 may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions such as limited

• Acknowledgments br Introduction Prostate cancer is

  2023-09-22

  

  Acknowledgments Introduction Prostate cancer is the first leading cause of cancer-related deaths among males in the UK and the second in the US. Despite recent advances in surgery, radiation, medical management and screening, prostate cancer patients suffer high morbidity and mortality and signi

• For all three fluorescent dyes

  2023-09-22

  

  For all three fluorescent dyes used, the double-labeled UQ-bodies showed higher antigen responses. A plausible mechanism for the higher quenching observed for the double-labeled UQ-bodies is the dye-dye quenching due to H-dimer formation [19] between the two dyes introduced into the Fd and L chains.

• br Author Contributions br Acknowledgments br Introduction C

  2023-09-22

  

  Author Contributions Acknowledgments Introduction Cerebral ischemia-reperfusion (I/R) injury is a pathological phenomenon that occurs after restoration of blood supply to Oxybutynin tissues subsequent to ischemia or hypoxia (Carden and Granger, 2000). It typically occurs after therapeutic t

• With regard to participation of the

  2023-09-22

  

  With regard to participation of the 12S-lipoxygenase in diabetes mellitus, inconsistent results have been obtained. Earlier studies demonstrated that the leukocyte-type 12S-lipoxygenase is specifically expressed in pancreatic b-cells and is involved in regulating glucose-stimulated insulin secretion

• br Potential and established risk factor for

  2023-09-22

  

  Potential and established risk factor for Alzheimer’s Disease The only way to overcome the above mentioned limitations is the identification of risk factors, which, taken together, can reliable predict the development of AD. Age and ApoE4 are established non-modifiable risk factors for AD. The ri

• Unexpectedly under pathological pain conditions inhibition

  2023-09-21

  

  Unexpectedly, under pathological pain conditions, inhibition of spinal glutamate transporter activity can produce antinociceptive effects. For example, intrathecal injection of the transportable inhibitor trans-pyrrolidine-2,4-dicarboxylic Benazepril HCl (t-PDC) or antisense oligonucleotides reduce

• Medium spiny neurons MSNs in the

  2023-09-21

  

  Medium spiny neurons (MSNs) in the striatum start from a deeply hyperpolarized resting membrane potential, slowly depolarize and show a delayed start of firing during a current injection (Kawaguchi, 1993, Nisenbaum and Wilson, 1995, Planert et al., 2013). The firing pattern during the current inject

15611 records 223/1041 page Previous Next First page 上5页 221222223224225 下5页 Last page