• Several ceritinib resistant mutations following the second

  2022-12-21

  

  Several ceritinib-resistant mutations following the second-line treatment of ALK+-NSCLC have been discovered [64]. These mutations include C1156Y, F1174L, and L1152R, which were first observed in crizotinib-resistant tumor samples. The G1202R ceritinib-resistant mutation occurs within the hinge and

• Thus far clinical data indicate that IDO inhibitors

  2022-12-21

  

  Thus far, clinical data indicate that IDO1 inhibitors have manageable toxicity, albeit with a relatively short period of treatment in a small number of patients. KYN is a pluripotent mediator and key intermediate for the synthesis of a host of downstream KP metabolites that are implicated in inflamm

• br Detection and possible treatments for prostate cancer PC

  2022-12-21

  

  Detection and possible treatments for prostate cancer PC can be diagnosed, by screening for prostate-specific antigen (PSA) and after diagnosis, treatments may include intense observation, radical prostatectomy, radiation, chemotherapy, hormone therapy or vaccination depending on the type and sta

• Fmoc-Ala-OMe Adenosine is a ubiquitous homeostatic substance

  2022-12-21

  

  Adenosine is a ubiquitous homeostatic substance released from most cells, including neurons and glias. Endogenous adenosine acts at four principal G-protein-associated receptor subtypes: A1, A2a, A2b and A3 (Ralevic and Burnstock, 1998). The stimulation of adenosine receptors by extracellular adenos

• Critically we found that pre treatment with A monomer prepar

  2022-12-16

  

  Critically we found that pre-treatment with Aβ monomer preparations prevented the Aβ oligomer-induced aggregation of PrPC. These preparations contain a mixture of Aβ species and consequently it was not possible to identify the precise form of Aβ that is responsible for this effect. It is possible th

• br The lipoxygenase pathway in diseases of the nervous

  2022-12-16

  

  The 12/15-lipoxygenase pathway in diseases of the nervous system Conclusions and future perspectives Arachidonic CU CPT 4a and other polyunsaturated fatty acids, and their lipid metabolites, play very important roles in human health and disease. This review has outlined the functions of 12- an

• This study revealed that EAAT expression was

  2022-12-15

  

  This study revealed that EAAT2 BMH-21 was increased 4–8 weeks after cauterization as our previous work (Park et al., 2009). RGC death could not be blocked despite activation of EAAT2, which is one of glutamate transporters in cone photoreceptors and some bipolar cells, in chronic ocular hypertensio

• Epithelial mesenchymal transition EMT is

  2022-12-15

  

  Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells are trans-differentiated into motile mesenchymal cells. During EMT, epithelial cells reorganize their cortical sitagliptin phosphate cytoskeleton, lose their junctions and apical-basal polarity, change cell shape, and r

• Axl has been reported to mediate cell cell adhesion

  2022-12-15

  

  Axl has been reported to mediate cell-cell adhesion and sphere-growth [11], [18] and to be important for metastasis to secondary organs [12], [14], [20]. We found an Axl-dependent CCRCC-ability of sphere-formation and repopulation after non-adhesive growth. Axl-inhibited cells could not attach to e

• arginase inhibitor br Conflicts of interest br Introduction

  2022-12-14

  

  Conflicts of interest Introduction Photodynamic Therapy (PDT) is a technique used for the treatment of several malignant and non malignant diseases (Akimoto, 2016, Keyal, Bhatta, Wang, 2016, Morton, Szeimies, Sidoroff, Wennberg, Basset-Seguin, Calzavara-Pinton, Gilaberte, Hofbauer, Hunger, Kar

• Introduction Antimicrobial resistance is a growing health th

  2022-12-14

  

  Introduction Antimicrobial resistance is a growing health threat worldwide that has been associated with incorrect prescription and overuse of ikk inhibitor [1]. Considering that physicians play a central role in antibiotic usage, a better understanding of their prescribing behaviours and their kno

• Negative regulation of AR expression by

  2022-12-14

  

  Negative regulation of AR expression by NFκB was also correlated with the ‘age-dependent desensitisation’ of androgen action in the rat liver (Supakar et al., 1995). In this case the binding site was mapped upstream of the gene to sequences −555 to −565 bp, that binds heterodimers of p65 and p50, as

• br Experimental section br Introduction

  2022-12-14

  

  Experimental section Introduction NMDA receptor-induced increases in AMPAR trafficking to the synaptic surface mediates changes in synaptic efficacy in a number of EPZ 005687 sale regions (Shi et al., 1999, Sun et al., 2005, Frenkel et al., 2006). While this process has been linked to the regu

• Cell surface metalloproteases coordinate signaling during de

  2022-12-14

  

  Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. A disintegrin and metalloprotease 17 (ADAM17) is a well-characterized member among ADAM family, which mediates the cleavage of various cell surface proteins (Black, 2002, Black et al., 1997, Dello

• Adiponectin is an adipokine whose

  2022-12-14

  

  Adiponectin is an adipokine whose circulating level is depleted in a number of metabolic diseases including insulin resistance, diabetes and cancer (Khan et al., 2015, Singh et al., 2014a, Singh et al., 2014b, Yamauchi et al., 2014). Despite its importance in health and pathophysiology, adiponectin

15629 records 319/1042 page Previous Next First page 上5页 316317318319320 下5页 Last page