• During the course of our research on

  2021-03-11

  

  During the course of our research on mGlu PAMs,, the hydroxyacetophenone scaffold was found to possess dual mGlu PAM and CysLT1 antagonism activity, presumably as orthosteric antagonist (). There is currently an increasing interest in drug discovery to explore multitarget drugs or polypharmacology

• In a study on the time

  2021-03-11

  

  In a study on the time course of a mechanism-based inactivation of CYP3A by HIV protease inhibitors, Katzenmaier et al. [37] reported that the suppression of CYP3A activity continued for threedays after the discontinuation of ritonavir. In the present study, the CYP3A activity on day 28 after a seve

• Placental insufficiency is regarded as the main etiology for

  2021-03-11

  

  Placental insufficiency is regarded as the main etiology for FGR. Placental development is highly unique in eutherians and is regulated by numerous factors. For example, the novel retrotransposon-derived gene retrotransposon-like 1 (RTL1) was recently shown to play a key role in placental developmen

• br Experimental br Declaration of interest br Introduction b

  2021-03-11

  

  Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR IGF-1, human recombinant library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound

• br Cholesterol handling in the arterial wall cells Foam cell

  2021-03-11

  

  Cholesterol handling in the arterial wall cells Foam cell formation in the arterial intima is a major hallmark of early-stage atherosclerotic lesions, which is attributed to uncontrolled uptake of modified lipoproteins, excess cholesterol esterification and impaired cholesterol release [44]. As a

• It seems plausible that this ESC driven effect relies

  2021-03-11

  

  It seems plausible that this ESC-driven effect relies on a paracrine signaling. Numerous studies showed that the Fgf4 (fibroblast growth factor 4)/MAPK (mitogen-activated protein kinase) pathway is involved in PE differentiation in mouse CFDA SE Cell Tracer Kit (Chazaud et al., 2006), (Frankenberg e

• br Methods br Discussion In a recent survey among

  2021-03-11

  

  Methods Discussion In a recent survey among 2625 high risk patients on atorvastatin, 10.5% of patients achieved an LDL-target of outcomes [[23], [24], [25], [26], [27]], our data suggests that clinical practice keeps the majority of our patients at harm. Antibodies to the proprotein convertas

• br Materials and methods br Results br Discussion The

  2021-03-11

  

  Materials and methods Results Discussion The nitric oxide generating enzymes of the NOS family comprise three isoforms: nNOS, iNOS and eNOS [31]. Expression of eNOS is mainly found in endothelial β-Sitosterol where it physically promotes vasodilation [32]. Conversely, evidence also indicat

• Our study revealed elevated basal Akt phosphorylation in die

  2021-03-11

  

  Our study revealed elevated basal Akt phosphorylation in diet-induced obesity, the effect of which was reversed by ETAKO. Activation of Akt promotes cardiac hypertrophy via a number of cellular mechanisms including activation of its downstream targets such as mTOR and GSK3β [45, 46]. Short-term acti

• Peramivir synthesis Materials and methods br Results Assay o

  2021-03-11

  

  Materials and methods Results Assay of botulinum toxin activity is critical for the risk-assessment, diagnosis, and treatment of botulism cases. The frequently encountered active forms of the toxin are; L chain (inside intoxicated neuronal cells), BoNT (in the blood stream of a botulism patient,

• Recently cross talk between DDR and the insulin

  2021-03-11

  

  Recently, cross-talk between DDR2 and the insulin receptor and between Notch1 and DDR1 was proposed. Stimulation of cells with collagen I and insulin promotes Tyr740 as well as total tyrosine phosphorylation of DDR2 receptor to a greater extent than the phosphorylation stimulated by collagen I alone

• As in our earlier observations the

  2021-03-11

  

  As in our earlier observations, the PTPN22 SNP affected the appearance of β-cell autoimmunity, but in contrast to our earlier report, only a borderline effect of the PTPN22 SNP on the progression to clinical disease was observed in the current analysis [22], [27]. The finding of an effect of the PTP

• In the past few years we

  2021-03-11

  

  In the past few years we and others have reported that GLP-1 may also be secreted by sub-populations of alpha Thiola in human pancreatic islets (Marchetti et al., 2012, Ellingsgaard et al., 2011), which could contribute to beta cell function and survival (Marchetti et al., 2012, Ellingsgaard et al.

• In the gel shown in Figure at early time points

  2021-03-11

  

  In the gel shown in Figure 8, at early time-points, 14% of the input dsDNA is converted to these intermediate species. These persist in the gel to later times, with approximately 50% of these being unwound. This unwinding occurs at a considerably slower rate and is due to that fraction of the popula

• OPP Although DGK is a lipid modulating enzyme

  2021-03-11

  

  Although DGKγ is a lipid-modulating enzyme, the role of DGKγ in integral cell metabolism has not been reported. We found that DGKγ made a difference on cell metabolism profile in HCC cells, which may be caused partially by the downregulation of GLUT1. Glucose is a major source of energy, and decreas

15642 records 654/1043 page Previous Next First page 上5页 651652653654655 下5页 Last page